Antihyperglycemic Effect of Pimpinella Tirupatiensis Leaves in Streptozotocin-Induced Diabetic Rats

Herbal therapies are commonly used to treat or manage various diseases including diabetes mellitus. Pimpinella tirupatiensis is Indian traditional medicine and the plant has been a popular remedy for various diseases such as antitumor genic, antimicrobial, purgative, analgesic, antiseptic, antipyretic and anti-inflammatory. The current study was intended to evaluate the antidiabetic efficacy of ethyl acetate extract of Pimpinella tirupatiensis leaves in streptozotocininduced diabetic rats. Diabetes was induced in male Sprague-Dawley rats by the administration of streptozotocin (55mg/kg body weight) intraperitoneally. Pimpinella tirupatiensis extract was administered to diabetic rats for 4 weeks. The extract effect (500 mg/ kg body weight) on serum glucose level, lipid profiles, serum aminotransferase (AST, ALT and ALP), creatinine, urea levels, body weight and also physiological parameters (food and water intake) were studied in diabetic rats. The serum glucose levels, lipid profiles (triglycerides and total cholesterol), serum aminotransferase (aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP)), creatinine and urea levels in streptozotocin-induced diabetic rats, were significantly (P<0.05) normalized after 4 weeks of Pimpinella tirupatiensis extract treatment. Furthermore, the body weight improved obviously in diabetic rats treated with Pimpinella tirupatiensis. Continuous treatment by administering Pimpinella tirupatiensis ethyl acetate extract (500 mg/kg b.w) orally to diabetic rats for 4 weeks reversed physiological parameters (food and water intake) and all the above-mentioned biochemical parameter changes in a noteworthy (P < 0.05) manner. This asserts that Pimpinella tirupatiensis ethyl acetate extract, which is efficacious in streptozotocin-induced diabetic rats, shall certainly be highly helpful in diabetes mellitus.